Mucosal protection against sulphide: importance of the enzyme rhodanese
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منابع مشابه
Protection against Mucosal Infections by Secretory IgA
In the past decade, several model systems have been developed to study the details of the production of secretory IgA by the mucosal surface. Until recently, most attention in vaccine research has been directed toward establishing a vigorous systemic (predominantly IgG) humoral immune response to the infectious agent. With the recognition, however, that secretory IgA is overwhelmingly the predo...
متن کاملProteolytic interconversion of electrophoretic variants of the enzyme rhodanese.
It has been confirmed that the enzyme rhodanese, although a homogeneous single polypeptide chain protein by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, is separable by electrophoresis under nondenaturing conditions into four species which differ in net surface charge (I-IV in the order of increasing positive charge). Limited proteolysis can interconvert these species. Chymotrypsi...
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The enzyme rhodanese (thiosulfate: cyanide sulfurtransferase) is a ubiquitous enzyme and its activity ispresent in all living organisms. Many functions including cyanide detoxification, formation of iron-sulfurcenters and participation in energy metabolism have been attributed to this enzyme. The enzyme catalyzesthe transfer of a sulfur atom from sulfane containing compounds (such as thiosulfat...
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The infant immune response to respiratory syncytial virus (RSV) remains incompletely understood. A neonatal mouse model of RSV infection mimics severe infection in human infants and have shed light on key immunological distinctions that explain disease severity and impaired immune responses in the youngest. Early activation of innate immunity, type 1 interferon dominated pathways (e.g. IFN alph...
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B ile is a complex mixture of organic and inorganic molecules that is stored in the gallbladder and released into the proximal small intestine when a meal is eaten. Bile is both an excretory secretion, to eliminate cholesterol, bilirubin, and waste products, and a digestive secretion, to promote lipid absorption. The dominant organic constituents of bile are conjugated bile acids (also termed b...
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ژورنال
عنوان ژورنال: Gut
سال: 2002
ISSN: 0017-5749
DOI: 10.1136/gut.50.2.201